1. To provide equipment, training, and expertise for imaging of macromolecular structures using cryo-Electron Microscopy (cryo-EM) coupled with single particle reconstruction.
    
2. To support a cryo-EM community at UC Davis dedicated to learning about, implementing, and evaluating cryo-EM methods and approaches.
    
3. To provide cryo-EM infrastructure and expertise to assist in grant-supported research on the UC Davis campus.
    
4. To provide a forum and resources for theoretical and practical education about cryo-EM.

Specifically, the BioEM Facility aims to provide users with the ability to evaluate the suitability of macromolecular samples for cryo-EM imaging by providing training and infrastructure in:

• sample preparation
• preliminary cryo-EM evaluation
• high-throughput data collection
• generation of preliminary 2D class averages for evaluation purposes

This level of support should be sufficient to provide preliminary data for funding proposals.